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Description for Protein PLCD1

phospholipase C, delta 1
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Phosphoinositide-specific phospholipase C (PLC) acts as a signal transducer that generates 2 second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, by hydrolyzing inositol phospholipids. PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • PH: Pleckstrin homology domain.
  • PLCXc: Phospholipase C, catalytic domain (part)
  • domain X
  • PLCYc: Phospholipase C, catalytic domain (part)
  • domain Y
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05857
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04020; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase delta 1; Phosphoinositide phospholipase C; PLC-delta-1; Phospholipase C-delta-1; PLC-III; Plc-Iii
    Approved Symbol:
    PLCD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acetate Ion(db);
  • D-Myo-Inositol-1,4,5-Triphosphate(db);
  • D-Myo-Inositol-2,4,5-Trisphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09073 Entrez Gene ID: 5333 OMIM ID: 602142 Swissprot Accession: P51178; B3KR14; A8K8F9;