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Description for Protein PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)
15 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05858
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04020; hsa04062; hsa04070; hsa04270; hsa04310; hsa04540; hsa04720; hsa04730; hsa04912; hsa04916; hsa04970; hsa05010; hsa05016; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PLC, beta 3
    Approved Symbol:
    PLCB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02577 Entrez Gene ID: 5331 OMIM ID: 600230 Swissprot Accession: Q01970;