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Description for Protein PLA2G2A

phospholipase A2, group IIA (platelets, synovial fluid)
8 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/2)
(platelet: 1; undefined: 1)
Summary:
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PA2c: Phospholipase A2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.4
    KEGG - Orthology:
    K01047
    KEGG - Pathway(s):
    hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04010; hsa04270; hsa04370; hsa04664; hsa04730; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phospholipase A2, synovial; PLA2S; PLAS1; Phospholipase A2 polypeptide B; PLA2B; MOM1
    Approved Symbol:
    PLA2G2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid(db);
  • 1,4-Butanediol(db);
  • 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid(db);
  • 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide(db);
  • 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene(db);
  • 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid(db);
  • 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid(db);
  • B-Octylglucoside(db);
  • Elaidoylamide(db);
  • Ginkgo biloba(db);
  • Indomethacin(db);
  • Isopropyl Alcohol(db);
  • Lauric Acid(db);
  • N-Tridecanoic Acid(db);
  • Suramin(db);
  • [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid(db)

    Associated Genetic Diseases:

  • Colorectal cancer, sporadic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01397 Entrez Gene ID: 5320 OMIM ID: 172411 Swissprot Accession: P14555;