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Description for Protein PLA2G1B

phospholipase A2, group IB (pancreas)
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PA2c: Phospholipase A2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.4
    KEGG - Orthology:
    K01047
    KEGG - Pathway(s):
    hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04010; hsa04270; hsa04370; hsa04664; hsa04730; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phospholipase A2, pancraetic; Phospholipase A2 polypeptide A; PLA2A; PLA2; Phosphatidylcholine 2-acylhydrolase; Group IB phospholipase A2
    Approved Symbol:
    PLA2G1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL(db);
  • 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • Acetate Ion(db);
  • Alpha-D-Mannose(db);
  • Cholic Acid(db);
  • Heptanoic Acid(db);
  • Hexane-1,6-Diol(db);
  • Lpc-Ether(db);
  • N-Tridecanoic Acid(db);
  • Niflumic Acid(db);
  • P-Anisic Acid(db);
  • PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER(db);
  • Pyruvoyl Group(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01396 Entrez Gene ID: 5319 OMIM ID: 172410 Swissprot Accession: P04054;