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Description for Protein PKP2

plakophilin 2
16 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ARM: Armadillo/beta-catenin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12642
    KEGG - Pathway(s):
    hsa05412
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ARVD9; Plakophilin 2 isoform 2b; Plakophilin 2 isoform 2a
    Approved Symbol:
    PKP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 42
    Human (de-) phosphorylation sites: 42; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Arrhythmogenic right ventricular dysplasia, familial, 9(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04177 Entrez Gene ID: 5318 OMIM ID: 602861 Swissprot Accession: A0AV37; Q99959;