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Description for Protein PKM2

pyruvate kinase, muscle
11 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/2)
(alpha granules: 2; cAMP/cGMP binding: 1; membrane: 2; microparticles: 2; phosphoproteome: 1; platelet: 9; secretome: 2; undefined: 1)
Summary:
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.40
KEGG - Orthology:
K00873
KEGG - Pathway(s):
hsa00010; hsa00230; hsa00620; hsa01100; hsa04930
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Thyroid hormone-binding protein, cytosolic; Cytosolic thyroid hormone-binding protein; Pyruvate kinase muscle isozyme; Pyruvate kinase, M1 isozyme; OPA-interacting protein 3; PK, muscle type; CTHBP; THBP1; OIP3; PKM; EC 2.7.1.40; MGC3932; PK3; Pyruvate kinase M 2; Pyruvate kinase 3 isoform 1; Pyruvate kinase 3 isoform 2; Pyruvate kinase, muscle
Approved Symbol:
PKM2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 17
Human (de-) phosphorylation sites: 17; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine(db);
  • 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine(db);
  • 2-Phosphoglycolic Acid(db);
  • 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one(db);
  • L-Phospholactate(db);
  • Oxalate Ion(db);
  • Pyruvic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01529 Entrez Gene ID: 5315 OMIM ID: 179050 Swissprot Accession: P14618;