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Description for Protein PIP4K2A

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(cAMP/cGMP binding: 1; platelet: 12; secretome: 1)
Summary:
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PIPKc: Phosphatidylinositol phosphate kinases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.149
    KEGG - Orthology:
    K00920
    KEGG - Pathway(s):
    hsa00562; hsa04070; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PIPK; PIP5KII-alpha; 1-phosphatidylinositol-4-phosphate kinase; Diphosphoinositide kinase; EC 2.7.1.149
    Approved Symbol:
    PIP4K2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11931 Entrez Gene ID: 5305 OMIM ID: 603140 Swissprot Accession: P48426;