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Description for Protein PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1
67 total interacting proteins; 29 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
Peptidyl-prolyl cis/trans isomerases (PPIases; EC 5.2.1.8), such as PIN1, catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. PIN1 is the only PPIase that specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. PIN1-catalyzed conformational regulation has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, germ cell development, neuronal differentiation, and survival (review by Lu and Zhou, 2007 [PubMed 17878917]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • WW: Domain with 2 conserved Trp (W) residues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.2.1.8
    KEGG - Orthology:
    K09578
    KEGG - Pathway(s):
    hsa04622
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Peptidyl-prolyl cis-trans isomerase NIMA interacting 1; Rotamase Pin1; PPIase Pin1; DOD
    Approved Symbol:
    PIN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,6,9,12,15,18-HEXAOXAICOSANE(db);
  • Beta-(2-Naphthyl)-Alanine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03031 Entrez Gene ID: 5300 OMIM ID: 601052 Swissprot Accession: Q13526;