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Description for Protein PI4KA

phosphatidylinositol 4-kinase, catalytic, alpha
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 2)
Summary:
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PI3KA: Phosphoinositide 3-kinase family, accessory domain (PIK domain)
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.67
    KEGG - Orthology:
    K00888
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PI4K-alpha; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 2; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 1; Phosphatidylinositol 4-kinase, type II, alpha; Phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase; PtdIns-4-kinase; Phosphatidylinositol 4 kinase, catalytic, alpha; Phosphatidylinositol 4-kinase 230
    Approved Symbol:
    PI4KA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08972 Entrez Gene ID: 5297 OMIM ID: 600286 Swissprot Accession: Q4LE69; P42356;