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Description for Protein PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
148 total interacting proteins; 93 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4; undefined: 1)
Summary:
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • SH2: Src homology 2 domains
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02649
    KEGG - Pathway(s):
    hsa04012; hsa04062; hsa04070; hsa04150; hsa04210; hsa04370; hsa04510; hsa04620; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04910; hsa04914; hsa04930; hsa04960; hsa05100; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GRB1; Phosphatidyl inositol 3 kinase associated p85 alpha; Phosphatidyl inositol 3 kinase regulatory 85 KD, alpha; p85 alpha; Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1; Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 2; Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 3
    Approved Symbol:
    PIK3R1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE(db);
  • Isoproterenol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01381 Entrez Gene ID: 5295 OMIM ID: 171833 Swissprot Accession: P27986;