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Description for Protein PIM1

pim-1 oncogene
14 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001 [PubMed 11518967]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04702
    KEGG - Pathway(s):
    hsa04630; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene PIM1; Proto oncogene serine/threonine protein kinase pim1
    Approved Symbol:
    PIM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 21
    Human phosphorylation targets: 12; Predicted platelet targets: 9
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile(db);
  • (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One(db);
  • (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile(db);
  • (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile(db);
  • 2,3-diphenyl-1H-indole-7-carboxylic acid(db);
  • 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One(db);
  • 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One(db);
  • 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one(db);
  • 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine(db);
  • 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE(db);
  • 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE(db);
  • Adenosine monophosphate(db);
  • Imidazole(db);
  • IMIDAZOPYRIDAZIN 1(db);
  • N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine(db);
  • N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db);
  • Phosphonoserine(db);
  • Quercetin(db);
  • Rbt205 Inhibitor(db);
  • S,S-(2-Hydroxyethyl)Thiocysteine(db);
  • Staurosporine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01292 Entrez Gene ID: 5292 OMIM ID: 164960 Swissprot Accession: P11309;