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Description for Protein PIK3CB

phosphoinositide-3-kinase, catalytic, beta polypeptide
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PI3KA: Phosphoinositide 3-kinase family, accessory domain (PIK domain)
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.153
    KEGG - Orthology:
    K00922
    KEGG - Pathway(s):
    hsa00562; hsa04012; hsa04062; hsa04070; hsa04150; hsa04210; hsa04370; hsa04510; hsa04620; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04910; hsa04914; hsa04930; hsa04960; hsa05100; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, beta isoform; Phosphoinositide 3-kinase, catalytic, beta polypeptide; Phosphatidylinositol 3-kinase, catalytic 110-KD beta; p110-beta; PI3-kinase p110 subunit beta; PtdIns-3-kinase p110; PI3K; PI3Kbeta
    Approved Symbol:
    PIK3CB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04234 Entrez Gene ID: 5291 OMIM ID: 602925 Swissprot Accession: P42338;