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Description for Protein PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide
34 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • PI3KA: Phosphoinositide 3-kinase family, accessory domain (PIK domain)
  • CC: Coiled Coil
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.153
    KEGG - Orthology:
    K00922
    KEGG - Pathway(s):
    hsa00562; hsa04012; hsa04062; hsa04070; hsa04150; hsa04210; hsa04370; hsa04510; hsa04620; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04910; hsa04914; hsa04930; hsa04960; hsa05100; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p110 alpha; PI3 kinase, p110, subunit alpha; PtdIns 3 kinase, p110
    Approved Symbol:
    PIK3CA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE(db)

    Associated Genetic Diseases:

  • Breast cancer, somatic(Pd);
  • Colorectal cancer, somatic(Pd);
  • Ovarian cancer, epithelial, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01382 Entrez Gene ID: 5290 OMIM ID: 171834 Swissprot Accession: P42336;