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Description for Protein ATP6V1E1

ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(platelet: 6; secretome: 2)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.3.14
KEGG - Orthology:
K02150
KEGG - Pathway(s):
hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATPase H+ transporting lysosomal subunit E; ATP6E; Vacuolar proton pump 31-KD Subunit; Vacuolar proton pump E subunit; V-ATPase 31 kDa subunit; P31; V-ATPase E subunit; Vacuolar ATP synthase subunit E
Approved Symbol:
ATP6V1E1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00163 Entrez Gene ID: 529 OMIM ID: 108746 Swissprot Accession: P36543; Q53Y06; A8MUE4;