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Description for Protein PIK3C2B

phosphoinositide-3-kinase, class 2, beta polypeptide
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
  • PX: PhoX homologous domain, present in p47phox and p40phox.
  • C2: Protein kinase C conserved region 2 (CalB)
  • PI3KA: Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.154
    KEGG - Orthology:
    K00923
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phosphatidylinositol 3 kinase, class 2, beta; PI3K C2beta; Phosphatidylinositol 3 kinase C2 domain containing beta polypeptide; PTDINS-3-kinase C2 beta
    Approved Symbol:
    PIK3C2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04160 Entrez Gene ID: 5287 OMIM ID: 602838 Swissprot Accession: O00750; A2RUF7;