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Description for Protein PIGF

phosphatidylinositol glycan anchor biosynthesis, class F
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.-.-
    KEGG - Orthology:
    K05287
    KEGG - Pathway(s):
    hsa00563; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GPI H; MGC32646; MGC33136; Phosphatidylinositol glycan, class F; Phosphatidylinositol glycan, class F isoform 1; Phosphatidylinositol glycan, class F isoform 2; PIG-F
    Approved Symbol:
    PIGF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 02539 Entrez Gene ID: 5281 OMIM ID: 600153 Swissprot Accession: Q07326; Q6IB04;