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Description for Protein ATP6V1C1

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.14
    KEGG - Orthology:
    K02148
    KEGG - Pathway(s):
    hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ATP6C; ATP6D; FLJ20057; VATC; Vma5; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 42kD; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 isoform A; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 isoform B; ATPase, H+ transporting, lysosomal, 42kD; ATPase, H+ transporting, lysosomal, subunit C; H(+)-transporting two-sector ATPase, subunit C; H+ -ATPase C subunit; H+ transporting; H+-transporting ATPase chain C, vacuolar; V-ATPase C subunit; Lysosomal (vacuolar proton pump) 42kD; Subunit C of vacuolar proton-ATPase V1 domain; Vacuolar proton pump C subunit; Vacuolar proton pump, 42-kD subunit; Vacuolar proton-ATPase, subunit C, VI domain; EC 3.6.3.14
    Approved Symbol:
    ATP6V1C1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • D-tartaric acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04371 Entrez Gene ID: 528 OMIM ID: 603097 Swissprot Accession: P21283;