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Description for Protein ATP6V1B2

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(ATP binding: 1; microparticles: 1; platelet: 3)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.3.14
KEGG - Orthology:
K02147
KEGG - Pathway(s):
hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATPase, H+ Transporting, lysosomal 56/58 KD, V1 subunit B, isoform 2; Vacuolar ATP synthase subunit B, brain isoform; V ATPase B2 subunit; Vacuolar proton pump B isoform 2; Endomembrane proton pump 58 kDa subunit; HO57; ATP6B2
Approved Symbol:
ATP6V1B2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE(db);
  • Gallium nitrate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06088 Entrez Gene ID: 526 OMIM ID: 606939 Swissprot Accession: P21281;