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Description for Protein SLC25A3

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 5)
Summary:
The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Phosphate carrier protein, mitochondrial; PTP; PiC; Phosphate carrier; OK/SW-cl.48; PHC; Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Mitochondrial phosphate carrier protein; Mitochondrial carrier; Solute carrier family 25 member 3 isoform b precursor; Solute carrier family 25 member 3 isoform a precursor
    Approved Symbol:
    SLC25A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mitochondrial phosphate carrier deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 02654 Entrez Gene ID: 5250 OMIM ID: 600370 Swissprot Accession: Q00325; Q6MZF9;