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Description for Protein PGR

progesterone receptor
49 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
  • HOLI: Ligand binding domain of hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08556
    KEGG - Pathway(s):
    hsa04114; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PR; NR3C3
    Approved Symbol:
    PGR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Allylestrenol(db);
  • Danazol(db);
  • Desogestrel(db);
  • Drospirenone(db);
  • Dydrogesterone(db);
  • Ethynodiol Diacetate(db);
  • Etonogestrel(db);
  • Fluticasone Propionate(db);
  • Levonorgestrel(db);
  • Medroxyprogesterone(db);
  • Megestrol(db);
  • Methyltrienolone(db);
  • Mifepristone(db);
  • Norelgestromin(db);
  • Norethindrone(db);
  • Norgestimate(db);
  • Norgestrel(db);
  • Progesterone(db);
  • Tanaproget(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07077 Entrez Gene ID: 5241 OMIM ID: 607311 Swissprot Accession: P06401;