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Description for Protein PGK1

phosphoglycerate kinase 1
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 6; secretome: 1)
Summary:
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.2.3
KEGG - Orthology:
K00927
KEGG - Pathway(s):
hsa00010; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PGKA
Approved Symbol:
PGK1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 11
Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Phosphoglyceric Acid(db);
  • Adenosine-5'-Diphosphate(db);
  • Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate(db)

    Associated Genetic Diseases:

  • PGK Alabama, hemolytic anemia and mental retardation due to(Pd);
  • PGK Amiens, hemolytic anemia due to(Pd);
  • PGK Hamamatsu, myopathy and myoglobinura due to(Pd);
  • PGK Herlev, hemolytic anemia due to(Pd);
  • PGK II(Pd);
  • PGK Matsue, nonspherocytic hemolytic anemia due to(Pd);
  • PGK Michigan, hemolytic anemia and mental retardation due to(Pd);
  • PGK Munchen(Pd);
  • PGK Shizuoka, hemolytic anemia and myoglobinuria due to(Pd);
  • PGK Tokyo, nonspherocytic hemolytic anemia due to(Pd);
  • PGK Uppsala, hemolytic anemia due to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02412 Entrez Gene ID: 5230 OMIM ID: 311800 Swissprot Accession: P00558; A8K4W6;