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Description for Protein ATP6V1A

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/0)
(ATP binding: 1; membrane: 2; microparticles: 1; platelet: 4; secretome: 1)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.3.14
KEGG - Orthology:
K02145
KEGG - Pathway(s):
hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATPase, H+ transporting, lysosomal alpha polypeptide, 70 KD, isoform 1; V ATPase A subunit 1; Vacuolar proton pump, alpha subunit 1; VA68; Vacuolar ATP synthase subunit B, brain isoform; V ATPase B2 subunit; Vacuolar proton pump B isoform 2; Endomembrane proton pump 58kDa subunit; HO57; ATP6V1B2; ATP6B; HO68
Approved Symbol:
ATP6V1A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alendronate(db);
  • Bafilomycin A1(db);
  • Bafilomycin B1(db);
  • Etidronic acid(db);
  • Tiludronate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06120 Entrez Gene ID: 523 OMIM ID: 607027 Swissprot Accession: P38606;