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Description for Protein PGD

phosphogluconate dehydrogenase
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(membrane: 1; microparticles: 1; platelet: 5; secretome: 1)
Summary:
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.44
KEGG - Orthology:
K00033
KEGG - Pathway(s):
hsa00030; hsa00480; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PGD, erythrocyte; 6PGD; 6 phosphogluconate dehydrogenase, decarboxylating; 6 phosphogluconate dehydrogenase, erythrocyte
Approved Symbol:
PGD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 6-Phosphogluconic Acid(db);
  • Dacarbazine(db);
  • Gadopentetate dimeglumine(db);
  • Ketotifen(db);
  • Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate(db);
  • Pyrophosphate 2-(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01391 Entrez Gene ID: 5226 OMIM ID: 172200 Swissprot Accession: P52209; A8K2Y9;