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Description for Protein PGAM2

phosphoglycerate mutase 2 (muscle)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.4.2.1
KEGG - Orthology:
K01834
KEGG - Pathway(s):
hsa00010; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phosphoglycerate mutase isozyme M; PGAM-M; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase
Approved Symbol:
PGAM2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Phosphoglyceric Acid(db);
  • Benzene Hexacarboxylic Acid(db)

    Associated Genetic Diseases:

  • Myopathy due to deficiency of muscle phosphoglycerate mutase(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02027 Entrez Gene ID: 5224 OMIM ID: 612931 Swissprot Accession: P15259;