Summary:
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11. (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K02131
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Nomenclature / Alternative Names:
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; Mitochondrial ATP synthase, subunit F6; Mitochondrial ATP synthase, coupling factor 6; ATP5; ATP synthase coupling factor 6, mitochondrial; ATPM; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 isoform b; ATP5A; Mitochondrial ATPase coupling factor 6; ATPase subunit F6; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 isoform a; F6; CF6
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Approved Symbol:
| (De-) Phosphorylations:
| Total (de-) phosphorylation sites: 0 |
| No human (de-) phosphorylation sites; | No platelet phosphorylation sites |
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
None Available
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 5 : 0
Isoform 4 : 0
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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