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Description for Protein PFN2

profilin 2
32 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PROF: Profilin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05759
    KEGG - Pathway(s):
    hsa04810; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Profilin 2 isoform b; Profilin 2 isoform a; D3S1319E; PFL; Profilin II
    Approved Symbol:
    PFN2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane(db);
  • 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01451 Entrez Gene ID: 5217 OMIM ID: 176590 Swissprot Accession: P35080;