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Description for Protein PFKP

phosphofructokinase, platelet
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(ATP binding: 1; membrane: 1; microparticles: 1; platelet: 15; secretome: 1; undefined: 1)
Summary:
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.11
KEGG - Orthology:
K00850
KEGG - Pathway(s):
hsa00010; hsa00030; hsa00051; hsa00052; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PFK, platelet type; PFK, fibroblast type; PFKF; F6-phosphofructokinase, type C; Phosphofructokinase 1; Phosphofructo-1-kinase isozyme C; PFK-C; 6-phosphofructokinase, platelet type
Approved Symbol:
PFKP
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01384 Entrez Gene ID: 5214 OMIM ID: 171840 Swissprot Accession: Q01813; B3KS15;