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Description for Protein PFKL

phosphofructokinase, liver
9 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/2)
(membrane: 1; microparticles: 1; platelet: 4; undefined: 2)
Summary:
Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. The protein encoded by this gene represents the L subunit. Alternate splicing results in two transcript variants, one of which is a candidate for nonsense-mediated decay (NMD). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.11
KEGG - Orthology:
K00850
KEGG - Pathway(s):
hsa00010; hsa00030; hsa00051; hsa00052; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PFK, liver type; 6-phosphofructokinase, liver type; Phosphofructokinase 1; Phosphohexokinase; Phosphofructo 1 kinase isozyme B; PFK-B; Liver phosphofructokinase isoform a; Liver phosphofructokinase isoform b
Approved Symbol:
PFKL
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01385 Entrez Gene ID: 5211 OMIM ID: 171860 Swissprot Accession: P17858; Q7L2M7;