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Description for Protein PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
9 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.105; 3.1.3.46
KEGG - Orthology:
K00900
K01103
KEGG - Pathway(s):
hsa00051
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PFKFB, cardiac; 6PF-2-K/Fru-2,6-P2ASE heart type isozyme; PFK-2/FBPase-2; Fructose-2,6-bisphosphatase, cardiac isozyme; Phosphofructokinase type 2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 isoform b; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 isoform a
Approved Symbol:
PFKFB2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 12
Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01383 Entrez Gene ID: 5208 OMIM ID: 171835 Swissprot Accession: O60825; Q5VVQ3;