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Description for Protein ACP1

acid phosphatase 1, soluble
14 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(microparticles: 1; platelet: 10)
Summary:
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.2; 3.1.3.48
    KEGG - Orthology:
    K01078
    K01104
    KEGG - Pathway(s):
    hsa00740; hsa04520
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acid phosphatase 1 isoform c; Acid phosphatase 1 Isoform b; Red cell acid phosphatase 1 isozyme F; ACP1-Bf; HAAP-alpha; HCPTP-A; HCPTP1-1; MGC3499; Adipocyte acid phosphatase; Red cell acid phosphatase 1; Protein tyrosine phosphatase; Acid phosphatase of erythrocyte; Cytoplasmic phosphotyrosyl protein phosphatase; Low molecular weight phosphotyrosine protein phosphatase; Acid phosphatase 1 isoform d; EC 3.1.3.48; LMW-PTPase; LMW-PTP; EC 3.1.3.2; Phosphatase, acid, of erythrocyte; ACP1; Acid phosphatase 1, soluble
    Approved Symbol:
    ACP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Nitrophenyl Phosphate(db);
  • Adenine(db)

    Associated Genetic Diseases:

  • Acid phosphatase 1, soluble, A/B polymorphism of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08881 Entrez Gene ID: 52 OMIM ID: 171500 Swissprot Accession: Q59EH3; P24666; B5MCC7;