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Description for Protein PFAS

phosphoribosylformylglycinamidine synthase
11 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.5.3
KEGG - Orthology:
K01952
KEGG - Pathway(s):
hsa00230; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phosphoribosylformylglycinamidine synthase (FGAR amidotransferase); FGAM synthase; FGAR amidotransferase; Formylglycinamide ribotide synthetase; Formylglycinamide ribotide amidotransferase; Phosphoribosylformylglycinamidine amidotransferase; FGARAT; FGAMS; EC 6.3.5.3
Approved Symbol:
PFAS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • L-Glutamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09072 Entrez Gene ID: 5198 OMIM ID: 602133 Swissprot Accession: A8K9T9; Q6P4B4; O15067;