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Description for Protein TUBA8

tubulin, alpha 8
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; microparticles: 1; platelet: 2; secretome: 2)
Summary:
This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TUBULIN: Tubulin/FtsZ family, GTPase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07374
    KEGG - Pathway(s):
    hsa04540; hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tubulin, alpha like 2; TUBAL2
    Approved Symbol:
    TUBA8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Epothilone B(db);
  • Epothilone D(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05763 Entrez Gene ID: 51807 OMIM ID: 605742 Swissprot Accession: Q9NY65;