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Description for Protein ZAK

sterile alpha motif and leucine zipper containing kinase AZK
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • CC: Coiled Coil
  • SAM: Sterile alpha motif.
  • NES: Nuclear Export Signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.25
    KEGG - Orthology:
    K04424
    KEGG - Pathway(s):
    hsa04010; hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MLK-related kinase isoform 2; MLK-related kinase isoform 1; Sterile alpha motif and leucine zipper containing kinase AZK; MLTK-alpha; MRK-alpha; Mlklak; Mixed lineage kinase related kinase; Mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase related kinase MRK-alpha; MLK like mitogen activated protein triple kinase
    Approved Symbol:

    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 51
    Human (de-) phosphorylation sites: 51; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11791 Entrez Gene ID: 51776 OMIM ID: 609479 Swissprot Accession: Q9NYL2;