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Description for Protein ERAP1

endoplasmic reticulum aminopeptidase 1
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 2; platelet: 3; secretome: 2)
Summary:
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.11.-
    KEGG - Orthology:
    K09604
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ALAP; Aminopeptidase regulator of TNFR1 shedding 1; ARTS1; Puromycin insensitive leucyl specific aminopeptidase; Endoplasmic reticulum aminopeptidase associated with antigen processing; ERAAP; Endoplasmic reticulum aminopeptidase 1; ERAP1; KIAA0525; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator isoform b; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator isoform a
    Approved Symbol:
    ERAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06015 Entrez Gene ID: 51752 OMIM ID: 606832 Swissprot Accession: Q9NZ08;