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Description for Protein CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; microparticles: 1; platelet: 3)
Summary:
Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis (Liou et al., 2002 [PubMed 11912132]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.4.-; 2.7.4.14
    KEGG - Orthology:
    K13800
    KEGG - Pathway(s):
    hsa00240; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UMP-CMPK; RP11-511I2.1
    Approved Symbol:
    CMPK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Cytidine-5'-Monophosphate(db);
  • Gemcitabine(db);
  • P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate(db);
  • Tetrafluoroaluminate Ion(db);
  • Uridine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18258 Entrez Gene ID: 51727 OMIM ID: 191710 Swissprot Accession: P30085; B2R6S5;