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Description for Protein ACSL5

acyl-CoA synthetase long-chain family member 5
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 2; platelet: 6)
Summary:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.2.1.3
    KEGG - Orthology:
    K01897
    KEGG - Pathway(s):
    hsa00071; hsa01100; hsa03320; hsa04146; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ACS2; Long chain fatty acid coenzyme A ligase 5; Acyl CoA synthetase long chain family member 5 isoform a; Acyl CoA synthetase long chain family member 5 isoform b; Acyl CoA synthetase 5; ACS5; EC 6.2.1.3; Long chain acyl CoA synthetase 5; Long chain fatty acid CoA ligase 5; Fatty acid CoA ligase long chain 5; FACL5; LACS 5
    Approved Symbol:
    ACSL5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 16139 Entrez Gene ID: 51703 OMIM ID: 605677 Swissprot Accession: Q9ULC5;