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Description for Protein PDPK1

3-phosphoinositide dependent protein kinase-1
46 total interacting proteins; 33 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(: 1)
Summary:
(PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K06276
    KEGG - Pathway(s):
    hsa03320; hsa04150; hsa04510; hsa04910; hsa04960; hsa05213; hsa05215; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PDK1; PkB-like1; 3-phosphoinositide dependent protein kinase-1 isoform 1; 3-phosphoinositide dependent protein kinase-1 isoform 2; EC 2.7.1.37; PkB kinase; PkB kinase like gene 1; Protein kinase; PRO0461; MGC20087; MGC35290; PkB-like
    Approved Symbol:
    PDPK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 21
    Human phosphorylation targets: 21; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA(db);
  • 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine(db);
  • 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine(db);
  • 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE(db);
  • 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione(db);
  • 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE(db);
  • 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE(db);
  • 7-Hydroxystaurosporine(db);
  • Celecoxib(db);
  • Inositol-(1,3,4,5)-Tetrakisphosphate(db);
  • Phosphonoserine(db);
  • Rbt205 Inhibitor(db);
  • Staurosporine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05556 Entrez Gene ID: 5170 OMIM ID: 605213 Swissprot Accession: O15530; Q9BRD5;