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Description for Protein SUFU

suppressor of fused homolog (Drosophila)
27 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06229
KEGG - Pathway(s):
hsa04340; hsa05200; hsa05217
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Supressor of fused; SUFUH; SUFUXL
Approved Symbol:
SUFU
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Medulloblastoma, dermoplastic(Pd);
  • Medulloblastoma, desmoplastic(Pd);
  • Medulloblastoma, desmoplastic, somatic(Pd);
  • Medulloblastoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06124 Entrez Gene ID: 51684 OMIM ID: 607035 Swissprot Accession: Q9UMX1;