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Description for Protein PDGFRB

platelet-derived growth factor receptor, beta polypeptide
66 total interacting proteins; 46 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC2: Immunoglobulin C-2 Type
  • Ig_LIKE: Immunoglobulin like
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05089
    KEGG - Pathway(s):
    hsa04010; hsa04020; hsa04060; hsa04510; hsa04540; hsa04810; hsa05200; hsa05214; hsa05215; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Platelet derived growth factor receptor, beta; PDGFR; PDGFR1
    Approved Symbol:
    PDGFRB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Becaplermin(db);
  • Dasatinib(db);
  • Imatinib(db);
  • Sorafenib(db);
  • Sunitinib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01423 Entrez Gene ID: 5159 OMIM ID: 173410 Swissprot Accession: P09619; Q59F04;