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Description for Protein MED15

mediator complex subunit 15
19 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Positive cofactor 2, glutamine/Q-rich-associated protein isoform a; Positive cofactor 2, glutamine/Q-rich-associated protein isoform b; TIG1; CAG7A; CTG7A; TIG-1; TNRC7; ARC105; PC2; Positive cofactor 2; Q-rich-associated protein; PC2 glutamine; MED15; TPA inducible gene-1; CTG repeat protein 7a; TPA inducible protein; Trinucleotide repeat containing 7; Activator-recruited cofactor, 105-kD; PC2-glutamine-rich-associated protein
    Approved Symbol:
    MED15
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12117 Entrez Gene ID: 51586 OMIM ID: 607372 Swissprot Accession: Q96RN5;