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Description for Protein HDAC7

histone deacetylase 7
31 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • NES: Nuclear Export Signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.5.1.98
    KEGG - Orthology:
    K11408
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DKFZP586J0917; HDAC7; Histone deacetylase 7A isoform d; Histone deacetylase 7A isoform c; HD7a; Histone deacetylase 7A isoform a; Histone deacetylase 7A isoform b
    Approved Symbol:
    HDAC7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 31
    Human (de-) phosphorylation sites: 31; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09133 Entrez Gene ID: 51564 OMIM ID: 606542 Swissprot Accession: Q8WUI4;