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Description for Protein PDGFA

platelet-derived growth factor alpha polypeptide
9 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PDGF: Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04359
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04510; hsa04540; hsa04810; hsa05200; hsa05214; hsa05215; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PDGF A-chain; Platelet-derived growth factor alpha chain; PDGF1; Platelet-derived growth factor alpha isoform 1 preproprotein; Platelet-derived growth factor alpha isoform 2 preproprotein; Platelet derived growth factor, alpha polypeptide; Platelet derived growth factor, A chain
    Approved Symbol:
    PDGFA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01424 Entrez Gene ID: 5154 OMIM ID: 173430 Swissprot Accession: P04085;