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Description for Protein LARS

leucyl-tRNA synthetase
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 4; secretome: 1)
Summary:
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.1.1.4
KEGG - Orthology:
K01869
KEGG - Pathway(s):
hsa00290; hsa00970
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
RNTLS; LEUS; LeuRS; LARS1; HSPC192; KIAA1352; FLJ10595; FLJ21788; EC 6.1.1.4; Leucine tRNA ligase
Approved Symbol:
LARS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Leucine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01042 Entrez Gene ID: 51520 OMIM ID: 151350 Swissprot Accession: Q9P2J5;