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Description for Protein PDE9A

phosphodiesterase 9A
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.35
    KEGG - Orthology:
    K13761
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CGMP-specific 3`,5`-cyclic phosphodiesterase type 9; Homo sapiens Phosphodiesterase 9A2; HSPDE9A2; Phosphodiesterase PDE9A21; EC 3.1.4.35; Phosphodiesterase 9A isoform b; Phosphodiesterase 9A isoform c; Phosphodiesterase 9A isoform d; Phosphodiesterase 9A isoform e; Phosphodiesterase 9A isoform f; Phosphodiesterase 9A isoform h; Phosphodiesterase 9A isoform i; Phosphodiesterase 9A isoform j; Phosphodiesterase 9A isoform k; Phosphodiesterase 9A isoform l; Phosphodiesterase 9A isoform m; Phosphodiesterase 9A isoform n; Phosphodiesterase 9A isoform o; Phosphodiesterase 9A isoform a; PDE9A10
    Approved Symbol:
    PDE9A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 46
    Human (de-) phosphorylation sites: 46; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-ISOBUTYL-1-METHYLXANTHINE(db);
  • Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    09115_20(0)
    09115_19(0)
    09115_18(0)
    09115_17(0)
    09115_16(0)
    09115_15(0)
    09115_14(0)
    09115_13(0)
    09115_12(0)
    09115_11(0)
    09115_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09115 Entrez Gene ID: 5152 OMIM ID: 602973 Swissprot Accession: O76083;