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Description for Protein PDE6G

phosphodiesterase 6G, cGMP-specific, rod, gamma
9 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K13759
KEGG - Pathway(s):
hsa00230; hsa04744
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PDEG; GMP-PDE gamma; Phosphodiesterase 6G, cGMP-specific, rod, gamma
Approved Symbol:
PDE6G
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-ISOBUTYL-1-METHYLXANTHINE(db);
  • Sildenafil(db);
  • Vardenafil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08914 Entrez Gene ID: 5148 OMIM ID: 180073 Swissprot Accession: P18545;