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Description for Protein REV1

REV1 homolog (S. cerevisiae)
7 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 2; secretome: 2)
Summary:
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • BRCT: breast cancer carboxy-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.-
    KEGG - Orthology:
    K03515
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    REV1; Rev1 like terminal deoxycytidyl transferase; Alpha integrin binding protein 80; AIBP80; REV1 like
    Approved Symbol:
    REV1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16202 Entrez Gene ID: 51455 OMIM ID: 606134 Swissprot Accession: Q9UBZ9;