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Description for Protein IP6K2

inositol hexakisphosphate kinase 2
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PIPKc: Phosphatidylinositol phosphate kinases
  • PINc: Large family of predicted nucleotide-binding domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.4.21
    KEGG - Orthology:
    K07756
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    IP6K2; PiUS; InsP6 kinase 2; Pi uptake stimulator; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; EC 2.7.4.21; Inositol hexaphosphate kinase 2 isoform a; Inositol hexaphosphate kinase 2 isoform b
    Approved Symbol:
    IP6K2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07380 Entrez Gene ID: 51447 OMIM ID: 606992 Swissprot Accession: Q9UHH9; B2RCP4;