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Description for Protein PDE4D

phosphodiesterase 4D, cAMP-specific
16 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins. (PubMed Links)
Domains and Motifs:
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K01120
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dunce like phosphodiesterase E3; PDE43; DPDE3
    Approved Symbol:
    PDE4D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one(db);
  • (R)-Rolipram(db);
  • (S)-Rolipram(db);
  • 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE(db);
  • 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol(db);
  • 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(db);
  • 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 3-ISOBUTYL-1-METHYLXANTHINE(db);
  • 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone(db);
  • 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid(db);
  • 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One(db);
  • Adenosine monophosphate(db);
  • Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid(db);
  • Dyphylline(db);
  • Ibudilast(db);
  • Iloprost(db);
  • Ketotifen(db);
  • Piclamilast(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02530 Entrez Gene ID: 5144 OMIM ID: 600129 Swissprot Accession: Q08499;