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Description for Protein PRKAG2

protein kinase, AMP-activated, gamma 2 non-catalytic subunit
16 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CBS: Domain in cystathionine beta-synthase and other proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07200
    KEGG - Pathway(s):
    hsa04910; hsa04920; hsa05410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AMPK gamma2; AMPK gamma-2 chain; 5`-AMP-activated protein kinase, gamma-2 subunit; Protein kinase, AMP-activated, gamma 2 non-catalytic subunit; AMP-activated protein kinase, gamma-2 subunit; AMP-activated protein kinase gamma2 subunit isoform a; AMP-activated protein kinase gamma2 subunit isoform c; AMP-activated protein kinase gamma2 subunit isoform b
    Approved Symbol:
    PRKAG2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 52
    Human (de-) phosphorylation sites: 52; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cardiomyopathy, familial hypertrophic, with Wolff-Parkinson-White syndrome(Pd);
  • Glycogen storage disease of heart, lethal congenital(Pd);
  • Wolff-Parkinson-White syndrome, childhood-onset(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04119 Entrez Gene ID: 51422 OMIM ID: 602743 Swissprot Accession: Q9UGJ0;