Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PDE4B

phosphodiesterase 4B, cAMP-specific
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K01120
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dunce like phosphodiesterase E4; PDE32; MGC126529; DPDE4; PDEIVB; Phosphodiesterase 4B, cAMP-specific; cAMP-specific 3 5-cyclic phosphodiesterase 4B; Phosphodiesterase 4B, cAMP-specific isoform 1; Phosphodiesterase 4B, cAMP-specific isoform 2; Phosphodiesterase 4B, cAMP-specific isoform 3
    Approved Symbol:
    PDE4B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (R)-Mesopram(db);
  • (R)-Rolipram(db);
  • (S)-Rolipram(db);
  • 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide(db);
  • 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester(db);
  • 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone(db);
  • 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid(db);
  • 8-Bromo-Adenosine-5'-Monophosphate(db);
  • Adenosine monophosphate(db);
  • Amrinone(db);
  • Caffeine(db);
  • Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid(db);
  • Dyphylline(db);
  • Enprofylline(db);
  • Filaminast(db);
  • Ibudilast(db);
  • Iloprost(db);
  • Ketotifen(db);
  • Papaverine(db);
  • Pentoxifylline(db);
  • Piclamilast(db);
  • S,S-(2-Hydroxyethyl)Thiocysteine(db);
  • Theobromine(db);
  • Theophylline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02528 Entrez Gene ID: 5142 OMIM ID: 600127 Swissprot Accession: Q07343; Q5TEK4; Q59GM8;